Biotin and derivatives
Medchemexpress LLC Biotin-PEG-biotin | 194920-55-3 | 99.3% | C26H44N6O6S2 | 10MG
Biotin-PEG-Biotin is a biotin-terminated polyethylene glycol (PEG) linker designed for use in PROTAC assembly and biotin-based affinity workflows. It provides dual biotin handles separated by a flexible PEG spacer, enabling conjugation, capture, and detection applications.
- Biotinylated at both ends for affinity capture and pull-down workflows.
- Peg spacer provides flexibility and improved solubility in polar organic solvents.
- High purity for research applications - 99.3%.
- Soluble in DMSO (~175 mg/mL); ultrasonic treatment may aid dissolution.
- Store protected from light and under inert atmosphere; follow cold storage guidance.
Medchemexpress LLC NHS-MMAF | 1404073-19-3 | 97.2% | 943.18 | 50 MG
NHS-MMAF is a modified MMAF extracted from patent WO2012143499, specifically intermediate 219. MMAF is a potent tubulin polymerization inhibitor and is used as an antitumor agent.
- Modified MMAF.
- Functions as a potent tubulin polymerization inhibitor.
- Used as an antitumor agent.
- Intended for research use only.
Medchemexpress LLC Bis-SS-C3-NHS ester | 98604-88-7 | 98.0% | 432.47 g/mol | C16H20N2O8S2 | 10 MG
Bis-SS-C3-NHS ester is a cleavable disulfide-containing N-hydroxysuccinimide (NHS) ester linker used for bioconjugation. It reacts with primary amines to form stable amide bonds, and the internal disulfide provides a reducible linkage for intracellular payload release, making it suitable for antibody-drug conjugate synthesis and conjugation method development.
- Cleavable disulfide linker for controlled payload release
- N-hydroxysuccinimide (NHS) ester reactive toward primary amines
- High purity suitable for research-scale conjugation
- Available in multiple small-scale pack sizes for method development
- Stable when stored sealed at -20°C and protected from moisture
Apexbio Technology LLC Biotin-16-dCTP 200ul (5 mM)
Biotin-16-dCTP is a biotinylated derivative of deoxycytidine triphosphate (dCTP) designed for enzymatic incorporation into nucleic acids during polymerase-mediated processes Structurally it consists of a dCTP core conjugated via a 16-atom spacer arm to a biotin moiety facilitating effective interaction with streptavidin This specific biotin-streptavidin binding affinity enables applications in nucleic acid labeling detection and affinity purification protocols PCR experiments indicate that biotin-16-dCTP incorporation by Taq polymerase can reach approximately 90% substitution without considerable reduction in amplification yield demonstrating greater polymerase compatibility compared to biotin-16-dUTP analogues
Medchemexpress LLC Biotin-DADOO (Biotinyl-3,6-dioxaoctanediamine) | 138529-46-1 | 98.0% | 1 G
Biotin-DADOO is an amine compound that contains biotin and functions as a biotinylation reagent. It acts as an amino component, involved in the nucleophilic ring-opening reaction of epoxidized ω-double bonds during the synthesis of biotinylated inhibitor derivatives. This reagent can be conjugated with carboxymethyl cellulose derivatives and is utilized in the synthesis of biotin-estradiol conjugates for enzyme immunoassays. It also finds application in influenza A research.
- Functions as a biotinylation reagent.
- Participates in nucleophilic ring-opening reactions during biotinylated inhibitor synthesis.
- Can be conjugated with carboxymethyl cellulose derivatives.
- Involved in the synthesis of biotin-estradiol conjugates for enzyme immunoassays.
- Used in influenza A research.
Medchemexpress LLC CD79B Human Biotin 20ug
Recombinant human CD79B extracellular domain, biotinylated via an Avi tag and produced in HEK293 cells with a C-terminal His tag. This product is intended for use in binding assays, ELISA, receptor interaction studies, and other immunology research requiring a biotinylated B-cell receptor component reagent.
- Biotinylated via Avi tag for streptavidin-based capture and detection.
- Expressed in mammalian cells to preserve native post-translational modifications.
- Includes C-terminal His tag to enable purification and detection.
- Suitable for binding assays, ELISA, and receptor interaction studies.
- Provided as a purified recombinant protein for research use.
Medchemexpress LLC Fluorescein biotin | 134759-22-1 | MFCD00132986 | ≥90.0% | 831.01 | C42H50N6O8S2 | 10 MG
Fluorescein biotin is a fluorescently labeled biotin conjugate used as a non-radioactive alternative to radioactive biotin for detecting and quantitating biotin-binding sites by fluorescence or absorbance. It is supplied as a dry powder; solutions are unstable and should be prepared fresh and protected from light.
- Used for fluorescent detection and quantitation of biotin-binding sites.
- Fluorescence or absorbance is quenched upon binding to avidin or streptavidin.
- Supplied as a dry powder; prepare fresh solutions because it is unstable in solution.
- Store at 4°C and protect from light to preserve activity.
- Typical excitation ~485 nm and emission ~535 nm.
Medchemexpress LLC Bis-PEG30-NHS ester | 1633.81 | 5 MG
Bis-PEG30-NHS ester is a non-cleavable 30-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is designed for various laboratory applications.
- Non-cleavable 30-unit PEG ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
Medchemexpress LLC PC azido-PEG3-NHS carbonate ester | 1802907-96-5 | MFCD29052189 | 98.7% | 640.60 g·mol⁻¹ | C26H36N6O13 | 5 MG
PC Azido-PEG3-NHS carbonate ester is a photocleavable, heterobifunctional linker designed for covalent labeling of primary amines and for introducing an azide handle for click chemistry. The reagent couples to amine groups via an NHS carbonate, and the photocleavable moiety enables light-triggered release of the attached cargo; supplied as a dry research reagent with recommended cold storage.
Medchemexpress LLC 2H-1,2-oxazine derivative (TFA salt) | 96.0% | 1165.34 g/mol | C57H87F3N8O14 | 25 MG
NHS-modified monomethyl auristatin F (TFA) is an NHS-activated MMAF derivative supplied as a trifluoroacetate salt and used as an intermediate in antibody-drug conjugate (ADC) linker synthesis. It is provided for research applications and is intended for building drug-linker conjugates.
- NHS-activated derivative suitable for conjugation to amines.
- Intended as an intermediate for antibody-drug conjugate synthesis.
- Purity around 96.0% by HPLC.
- Molecular weight approximately 1165.34 g/mol.
- Provided as a TFA salt with formula C57H87F3N8O14.
Medchemexpress LLC Mal-PEG1-NHS ester | 1807518-72-4 | 310.26 g/mol | C13H14N2O7 | 1 G
Mal-PEG1-NHS ester is a PEG-based bifunctional linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester. It is used for bioconjugation in the synthesis of antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs), enabling selective thiol-to-amine coupling via maleimide and NHS chemistries.
- Bifunctional maleimide and NHS ester chemistry for thiol and amine coupling.
- PEG spacer increases solubility and reduces steric hindrance.
- Non-cleavable linker suitable for ADC and PROTAC synthesis.
- Available in multiple pack sizes, including 1 g for preparative use.
- Molecular weight 310.26 g/mol and formula C13H14N2O7.
Medchemexpress LLC DSPE-Biotin | 133695-76-8 | 97.5% | 974.36 g·mol⁻¹ | C51H96N3O10PS | 100 MG
DSPE-Biotin is a biotin-functionalized phospholipid used to introduce biotin groups into lipid membranes and liposome surfaces for biochemical and bioconjugation applications. It enables high-affinity capture and labeling of lipid particles via streptavidin/avidin interactions and is supplied for research use with recommended storage protected from light at low temperature.
- Biotin-functionalized phospholipid for membrane and liposome functionalization.
- Enables high-affinity binding to streptavidin/avidin systems for capture and targeting.
- Suitable for bioconjugation, labeling, and assay development with lipid particles.
- High reported purity (97.5%).
- Supplied as 100 MG and intended for research use only.
- Store protected from light at -20 °C for long-term stability.
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 100 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. PROTACs typically consist of two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Serves as a linker in the construction of PROTACs
- Linker is based on Polyethylene Glycol (PEG)
- Intended for research purposes only
- Primary application is in the synthesis of PROTACs
eMolecules 943858-70-6 | Azidobutyric acid NHS ester | Broadpharm | MFCD22573606 | 226.192 | C8H10N4O4 | 95.000 | [N-]=[N+]=NCCCC(=O)ON1C(=O)CCC1=O | 100mg | 550804169
Azidobutyric acid NHS ester | Broadpharm | 943858-70-6 | MFCD22573606 | 226.192 | C8H10N4O4 | 95.000 | [N-]=[N+]=NCCCC(=O)ON1C(=O)CCC1=O | 100mg | 550804169
Apexbio Technology LLC Concanavalin A (Con A)-Biotin 5x5mg(5 mg/mL)
Concanavalin A (Con A) is a lectin protein derived from Canavalia ensiformis (jack bean) with a molecular weight of approximately 104 kDa Each subunit can bind one Ca2 and one Mn2 ion and contains a carbohydrate-binding site Upon binding these metal ions Con A specifically binds to glycoproteins glycolipids and carbohydrates containing -D-glucose and -D-mannose residues Biotin is a small-molecule water-soluble vitamin that exhibits very strong affinity to avidin Concanavalin A-Biotin is a labeled protein conjugate composed of Concanavalin A linked to biotin widely used in biological research especially for detecting and quantifying biomolecules containing specific carbohydrate structures through immunohistochemistry (IHC) immunocytochemistry (ICC) and enzyme-linked immunosorbent assay (ELISA)