Biotin and derivatives
Medchemexpress LLC 2H-1,2-oxazine derivative (TFA salt) | 96.0% | 1165.34 g/mol | C57H87F3N8O14 | 25 MG
NHS-modified monomethyl auristatin F (TFA) is an NHS-activated MMAF derivative supplied as a trifluoroacetate salt and used as an intermediate in antibody-drug conjugate (ADC) linker synthesis. It is provided for research applications and is intended for building drug-linker conjugates.
- NHS-activated derivative suitable for conjugation to amines.
- Intended as an intermediate for antibody-drug conjugate synthesis.
- Purity around 96.0% by HPLC.
- Molecular weight approximately 1165.34 g/mol.
- Provided as a TFA salt with formula C57H87F3N8O14.
Medchemexpress LLC Mal-PEG1-NHS ester | 1807518-72-4 | 310.26 g/mol | C13H14N2O7 | 1 G
Mal-PEG1-NHS ester is a PEG-based bifunctional linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester. It is used for bioconjugation in the synthesis of antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs), enabling selective thiol-to-amine coupling via maleimide and NHS chemistries.
- Bifunctional maleimide and NHS ester chemistry for thiol and amine coupling.
- PEG spacer increases solubility and reduces steric hindrance.
- Non-cleavable linker suitable for ADC and PROTAC synthesis.
- Available in multiple pack sizes, including 1 g for preparative use.
- Molecular weight 310.26 g/mol and formula C13H14N2O7.
Medchemexpress LLC DSPE-Biotin | 133695-76-8 | 97.5% | 974.36 g·mol⁻¹ | C51H96N3O10PS | 100 MG
DSPE-Biotin is a biotin-functionalized phospholipid used to introduce biotin groups into lipid membranes and liposome surfaces for biochemical and bioconjugation applications. It enables high-affinity capture and labeling of lipid particles via streptavidin/avidin interactions and is supplied for research use with recommended storage protected from light at low temperature.
- Biotin-functionalized phospholipid for membrane and liposome functionalization.
- Enables high-affinity binding to streptavidin/avidin systems for capture and targeting.
- Suitable for bioconjugation, labeling, and assay development with lipid particles.
- High reported purity (97.5%).
- Supplied as 100 MG and intended for research use only.
- Store protected from light at -20 °C for long-term stability.
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 100 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. PROTACs typically consist of two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Serves as a linker in the construction of PROTACs
- Linker is based on Polyethylene Glycol (PEG)
- Intended for research purposes only
- Primary application is in the synthesis of PROTACs
Apexbio Technology LLC Concanavalin A (Con A)-Biotin 5x5mg(5 mg/mL)
Concanavalin A (Con A) is a lectin protein derived from Canavalia ensiformis (jack bean) with a molecular weight of approximately 104 kDa Each subunit can bind one Ca2 and one Mn2 ion and contains a carbohydrate-binding site Upon binding these metal ions Con A specifically binds to glycoproteins glycolipids and carbohydrates containing -D-glucose and -D-mannose residues Biotin is a small-molecule water-soluble vitamin that exhibits very strong affinity to avidin Concanavalin A-Biotin is a labeled protein conjugate composed of Concanavalin A linked to biotin widely used in biological research especially for detecting and quantifying biomolecules containing specific carbohydrate structures through immunohistochemistry (IHC) immunocytochemistry (ICC) and enzyme-linked immunosorbent assay (ELISA)
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 5 G
Biotin-EDA is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs themselves consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, leveraging the intracellular ubiquitin-proteasome system to degrade target proteins selectively.
- Utilized in the synthesis of PROTACs
- PROTACs consist of two different ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- The other ligand targets a specific protein
- Leverages the intracellular ubiquitin-proteoteasome system to degrade target proteins selectively
- Alkyl-chain based
Medchemexpress LLC Mal-PEG8-NHS ester | 2055033-05-9 | 99.0% | 250 MG
Mal-PEG8-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) are molecules that harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Consists of two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for the target protein
Medchemexpress LLC Biotin-PEG12-NHS ester | 1934296-88-4 | 99.3% | C41H72N4O18S | 100 MG
Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. This compound utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
- For research use only
Medchemexpress LLC CA125 Human Biotin 20ug | 20ug
The CA125 protein acts by binding to MSLN and plays a crucial role in forming a protective and lubricating barrier on mucosal surfaces This interaction promotes heterotypic cell adhesion and is suggested to play an important role in peritoneal metastasis of ovarian cancer CA125 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived CA125 protein expressed by HEK293 with C-Avi C-His labeled tag
![eMolecules 2252392-53-1 | Azido-PEG11-alcohol | Broadpharm | MFCD29052166 | 527.612 | C22H45N3O11 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 1g | 296213197](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203274.JPG-250.jpg)
eMolecules 2252392-53-1 | Azido-PEG11-alcohol | Broadpharm | MFCD29052166 | 527.612 | C22H45N3O11 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 1g | 296213197
Azido-PEG11-alcohol | Broadpharm | 2252392-53-1 | MFCD29052166 | 527.612 | C22H45N3O11 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 1g | 296213197
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 50 MG
Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent, containing an Azide group, and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC PCSK9 Human Biotin 5ug | 5ug
The PCSK9 protein is an important regulator of plasma cholesterol homeostasis affecting LDL receptor family members such as LDLR and VLDLR It promotes their intracellular degradation and enhances hepatic LDLR degradation through non-proteolytic mechanisms PCSK9 Protein Human (Biotinylated HEK293 D374Y His-Avi) is the recombinant human-derived PCSK9 protein expressed by HEK293 with C-Avi C-His labeled tag and D374Y mutation
Medchemexpress LLC FP-Biotin | 259270-28-5 | 99.1% | 592.75 | 10 MM * 1 ML
FP-Biotin is a potent organophosphorus toxicant suitable for identifying new biomarkers of organophosphorus toxicant exposure. It quantifies the activity of FAAH, ABHD6, and MAG-lipase. It is used in plasma studies where biotinylated peptides can be easily purified by binding to immobilized avidin beads. FP-Biotin demonstrates good reactivity with human AChE and BChE and is suitable for identifying organophosphorus toxicants reactive proteins.
- Potent organophosphorus toxicant
- Suitable for identifying new biomarkers of organophosphorus toxicant exposure
- Quantifies FAAH, ABHD6, and MAG-lipase activity
- Useful in plasma studies for easy purification of biotinylated peptides
- Reacts well with human AChE and BChE
- Identifies organophosphorus toxicants reactive proteins
Medchemexpress LLC 4,7,10,13,16,19-hexaoxaheneicosanoic acid, 21-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-2,5-dioxo-1-pyrrolidinyl ester | 1599472-25-9 | 98.0% | 530.52 | C23H34N2O12 | 250 MG
Mal-PEG6-NHS ester is a noncleavable ADC linker that combines a thiol-reactive maleimide, a six-unit polyethylene glycol spacer, and an amine-reactive N-hydroxysuccinimide (NHS) ester. It is supplied for research conjugation applications and is formulated as a colorless to light yellow liquid.
- Noncleavable linker with maleimide and NHS reactive groups.
- Six-unit PEG spacer increases hydrophilicity and solubility.
- High purity (98.0%) suitable for research conjugation.
- Molecular weight approximately 530.52 daltons.
- Soluble in DMSO (100 mg/mL); ultrasonic assistance recommended.
- Store protected from light at -20°C; in solvent store at -80°C for long-term.
Medchemexpress LLC M-PEG11-NHS ester | 3119903-67-9 | C28H51NO15 | 25 MG
M-PEG11-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker